ESR1 oncogenic variants
About
Gene context: ESR1
Biomarker Type: Somatic Variant
Present: True
Chromosome: 6
Requires Oncogenic: True
Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
Mappings
Therapeutic response
Precision oncology relationships for therapeutic response involving this biomarker.
| Organization(s) | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| EMA (1) FDA (1) | ER positive, ESR1 oncogenic variants, HER2-negative | Invasive Breast Carcinoma | Elacestrant | |
| FDA (1) | ER positive, ESR1 oncogenic variants, HER2-negative | Invasive Breast Carcinoma | Imlunestrant |