KRAS

About

Location: 12p12.1

Mappings

HGNC: HGNC:6407

Ensembl: NM_004985.5

NCBI: ENSG00000133703

Refseq: 3845

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Biomarkers

KRAS is involved in the following curated biomarkers.

Name Biomarker type Propositions Statements
Wild type KRAS Wild type 11 12
KRAS p.G12C Somatic Variant 4 6
KRAS p.G12V Somatic Variant 1 1

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Type Biomarker(s) Cancer type Therapy(ies)
Sensitivity (+) KRAS p.G12C Non-Small Cell Lung Cancer Adagrasib
Sensitivity (+) EGFR positive, Wild type KRAS Colorectal Adenocarcinoma Cetuximab, Fluorouracil, Irinotecan
Sensitivity (+) EGFR positive, Wild type KRAS Colorectal Adenocarcinoma Cetuximab, Irinotecan
Sensitivity (+) EGFR positive, Wild type KRAS Colorectal Adenocarcinoma Cetuximab
Sensitivity (+) Wild type HRAS, Wild type KRAS Colorectal Adenocarcinoma Fluorouracil, Oxaliplatin, Panitumumab
Sensitivity (+) Wild type HRAS, Wild type KRAS Colorectal Adenocarcinoma Panitumumab
Sensitivity (+) KRAS p.G12C Non-Small Cell Lung Cancer Sotorasib
Sensitivity (+) KRAS p.G12C Colorectal Adenocarcinoma Adagrasib, Cetuximab
Sensitivity (+) KRAS p.G12C Low-Grade Serous Ovarian Cancer Avutometinib, Defactinib
Sensitivity (+) KRAS p.G12V Low-Grade Serous Ovarian Cancer Avutometinib, Defactinib
Sensitivity (+) EGFR positive, Wild type HRAS, Wild type KRAS, Wild type NRAS Colorectal Adenocarcinoma Cetuximab
Sensitivity (+) EGFR positive, Wild type HRAS, Wild type KRAS, Wild type NRAS Colorectal Adenocarcinoma Cetuximab, Irinotecan
Sensitivity (+) EGFR positive, Wild type HRAS, Wild type KRAS, Wild type NRAS Colorectal Adenocarcinoma Cetuximab, Fluorouracil, Oxaliplatin
Sensitivity (+) KRAS p.G12C Non-Small Cell Lung Cancer Adagrasib
Sensitivity (+) KRAS p.G12C Non-Small Cell Lung Cancer Sotorasib
Sensitivity (+) Wild type KRAS, Wild type NRAS Colorectal Adenocarcinoma Fluorouracil, Oxaliplatin, Panitumumab
Sensitivity (+) Wild type KRAS, Wild type NRAS Colorectal Adenocarcinoma Fluorouracil, Irinotecan, Panitumumab
Sensitivity (+) Wild type KRAS, Wild type NRAS Colorectal Adenocarcinoma Fluorouracil, Irinotecan, Panitumumab
Sensitivity (+) Wild type KRAS, Wild type NRAS Colorectal Adenocarcinoma Panitumumab