TP53
About
Location: 17p13.1
Mappings
Biomarkers
TP53 is involved in the following curated biomarkers.
| Name | Biomarker type | Propositions | Statements |
|---|---|---|---|
| TP53 somatic variants | Somatic Variant | 2 | 2 |
| TP53 deletion | Copy Number | 2 | 2 |
| Wild type TP53 | Wild type | 1 | 1 |
Therapeutic response
Precision oncology relationships for therapeutic response involving this gene.
| Type | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| Sensitivity (+) | TP53 somatic variants | Chronic Lymphocytic Leukemia | Venetoclax | |
| Sensitivity (+) | TP53 deletion | Chronic Lymphocytic Leukemia | Venetoclax | |
| Sensitivity (+) | Wild type TP53 | Chronic Lymphocytic Leukemia | Venetoclax | |
| Sensitivity (+) | TP53 deletion | Chronic Lymphocytic Leukemia | Idelalisib, Rituximab | |
| Sensitivity (+) | TP53 somatic variants | Chronic Lymphocytic Leukemia | Idelalisib, Rituximab |