IDH1

Biomarkers

IDH1 is involved in the following curated biomarkers.

Name	Biomarker type	Propositions	Statements
IDH1 p.R132H	Somatic Variant	7	12
IDH1 p.R132G	Somatic Variant	7	12
IDH1 p.R132C	Somatic Variant	7	12
IDH1 p.R132S	Somatic Variant	7	12
IDH1 p.R132L	Somatic Variant	7	12

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Organization(s)	Biomarker(s)	Cancer type	Therapy(ies)
FDA (2)	IDH1 p.R132H	Acute Myeloid Leukemia	Ivosidenib
EMA (1) FDA (1)	IDH1 p.R132H	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
FDA (1)	IDH1 p.R132H	Myelodysplastic Syndromes	Ivosidenib
EMA (1) FDA (1)	IDH1 p.R132H	Cholangiocarcinoma	Ivosidenib
FDA (1)	IDH1 p.R132H	Acute Myeloid Leukemia	Olutasidenib
EMA (1) FDA (1)	IDH1 p.R132H	Astrocytoma	Vorasidenib
EMA (1) FDA (1)	IDH1 p.R132H	Oligodendroglioma	Vorasidenib
FDA (2)	IDH1 p.R132G	Acute Myeloid Leukemia	Ivosidenib
EMA (1) FDA (1)	IDH1 p.R132G	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
FDA (1)	IDH1 p.R132G	Myelodysplastic Syndromes	Ivosidenib
EMA (1) FDA (1)	IDH1 p.R132G	Cholangiocarcinoma	Ivosidenib
FDA (1)	IDH1 p.R132G	Acute Myeloid Leukemia	Olutasidenib
EMA (1) FDA (1)	IDH1 p.R132G	Astrocytoma	Vorasidenib
EMA (1) FDA (1)	IDH1 p.R132G	Oligodendroglioma	Vorasidenib
FDA (2)	IDH1 p.R132C	Acute Myeloid Leukemia	Ivosidenib
EMA (1) FDA (1)	IDH1 p.R132C	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
FDA (1)	IDH1 p.R132C	Myelodysplastic Syndromes	Ivosidenib
EMA (1) FDA (1)	IDH1 p.R132C	Cholangiocarcinoma	Ivosidenib
FDA (1)	IDH1 p.R132C	Acute Myeloid Leukemia	Olutasidenib
EMA (1) FDA (1)	IDH1 p.R132C	Astrocytoma	Vorasidenib
EMA (1) FDA (1)	IDH1 p.R132C	Oligodendroglioma	Vorasidenib
FDA (2)	IDH1 p.R132S	Acute Myeloid Leukemia	Ivosidenib
EMA (1) FDA (1)	IDH1 p.R132S	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
FDA (1)	IDH1 p.R132S	Myelodysplastic Syndromes	Ivosidenib
EMA (1) FDA (1)	IDH1 p.R132S	Cholangiocarcinoma	Ivosidenib
FDA (1)	IDH1 p.R132S	Acute Myeloid Leukemia	Olutasidenib
EMA (1) FDA (1)	IDH1 p.R132S	Astrocytoma	Vorasidenib
EMA (1) FDA (1)	IDH1 p.R132S	Oligodendroglioma	Vorasidenib
FDA (2)	IDH1 p.R132L	Acute Myeloid Leukemia	Ivosidenib
EMA (1) FDA (1)	IDH1 p.R132L	Acute Myeloid Leukemia	Azacitidine, Ivosidenib
FDA (1)	IDH1 p.R132L	Myelodysplastic Syndromes	Ivosidenib
EMA (1) FDA (1)	IDH1 p.R132L	Cholangiocarcinoma	Ivosidenib
FDA (1)	IDH1 p.R132L	Acute Myeloid Leukemia	Olutasidenib
EMA (1) FDA (1)	IDH1 p.R132L	Astrocytoma	Vorasidenib
EMA (1) FDA (1)	IDH1 p.R132L	Oligodendroglioma	Vorasidenib