Trastuzumab deruxtecan

About

Therapy type: Targeted therapy

Therapy strategy: HER2 inhibition

Mappings

NCI Thesaurus: Trastuzumab Deruxtecan (ncit:C128799)

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Therapeutic response

Precision oncology relationships for therapeutic response involving this therapy.

Type Biomarker(s) Cancer type Therapy(ies)
Sensitivity (+) HER2-positive Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) HER2-low Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) ERBB2 oncogenic variants Non-Small Cell Lung Cancer Trastuzumab deruxtecan
Sensitivity (+) HER2-positive Adenocarcinoma of the Gastroesophageal Junction Trastuzumab deruxtecan
Sensitivity (+) HER2-positive Any solid tumor Trastuzumab deruxtecan
Sensitivity (+) HER2-positive Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) HER2-low Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) ERBB2 oncogenic variants Non-Small Cell Lung Cancer Trastuzumab deruxtecan
Sensitivity (+) ERBB2 amplification Non-Small Cell Lung Cancer Trastuzumab deruxtecan
Sensitivity (+) HER2-positive Adenocarcinoma of the Gastroesophageal Junction Trastuzumab deruxtecan
Sensitivity (+) ERBB2 amplification Adenocarcinoma of the Gastroesophageal Junction Trastuzumab deruxtecan
Sensitivity (+) ER positive, HER2-low Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) HER2-low, PR positive Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) ER positive, HER2-low, PR positive Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) ER positive, HER2-ultralow Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) HER2-ultralow, PR positive Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) ER positive, HER2-ultralow, PR positive Invasive Breast Carcinoma Trastuzumab deruxtecan